,Waleed Nassar JAFFAL ,Dhuha Ahmed ABBAS
The effect of Reactive oxygen in male infertility in al- Anbar province / west of Iraq
Reactive oxygen species (ROS) are produced in the male genital tract by spermatozoa and leukocytes, such as neutrophils and macrophages. The regulation of sperm activities, including acrosome responses and capacitation, is mediated by ROS. As a first line of defense, neutrophils and macrophages undergo a "oxidative burst" as a result of high ROS generation brought on by infections. Infection causes an imbalance of pro- and antioxidants favoring the former, which causes oxidative stress and inhibits motility and fertilization of sperm as well as the previously described functions. Because of the increased contact time and absence of antioxidant defense, ROS produced during testis and epididymis infections is extremely damaging to sperm. Only extremely high levels of ROS-producing leukocytes are detrimental to sperm functions in the final ejaculate.
Anahtar Kelimeler: Vertigo, Anti-inflammatory drugs, ZIC-HILIC, Betahistine, Tablet dosage forms
The effect of Reactive oxygen in male infertility in al- Anbar province / west of Iraq
Reactive oxygen species (ROS) are produced in the male genital tract by spermatozoa and leukocytes, such as neutrophils and macrophages. The regulation of sperm activities, including acrosome responses and capacitation, is mediated by ROS. As a first line of defense, neutrophils and macrophages undergo a "oxidative burst" as a result of high ROS generation brought on by infections. Infection causes an imbalance of pro- and antioxidants favoring the former, which causes oxidative stress and inhibits motility and fertilization of sperm as well as the previously described functions. Because of the increased contact time and absence of antioxidant defense, ROS produced during testis and epididymis infections is extremely damaging to sperm. Only extremely high levels of ROS-producing leukocytes are detrimental to sperm functions in the final ejaculate.
Keywords: Vertigo, Anti-inflammatory drugs, ZIC-HILIC, Betahistine, Tablet dosage forms
Sayfa Aralığı: 187-192
Atıf İçin
Al-Janabi, A. O. F., Jaffal, W. N. & Abbas, D. A. (2022). The effect of Reactive oxygen in male infertility in al- Anbar province / west of Iraq. Journal of Current Researches on Health Sector, 12 (2), 187-192.