Evaluation of interleukin-6 level in the sera of children with UTI in Kirkuk city, Iraq

Urinary tract infection is the most common community acquired infections, also nosocomial acquired among children. The level of (IL-6) either in serum or in urine may reflect the disease severity in patients with different forms of urinary tract infection, as well as the bacterial cause implicated. So the aim of the study was to evaluate the serum IL-6 level in pediatric UTI less than 10 years in Kirkuk city Iraq. ELISA technique was performed to evaluate IL-6 level in patient's serum. The results showed that there is a relation between UTI infection and IL-6 level. Level of IL-6 elevates among children in cases of positive urine culture more than negative cases, recording (mean ± standard deviation) for positive urine culture of bacterial cause (77.56±33.84) comparing with control group (7.6±2.16). Level of IL-6 elevated among age group (6-10years) and in cases of infection with E. coli. Level of IL-6 elevate among male more than female in cases of UTI. Furthermore, children suffered cystitis recorded a higher mean value (88.21 ng/L) than children with pyelonephritis (17.83 ng/L) as well as F. value= (3.54) at df= (2) were significant at level (p ≤ 0.05).

Anahtar Kelimeler: Interleukin 6, Pediatric UTI, cystitis, pyelonephritis, Bacterial cause

Urinary tract infection is the most common community acquired infections, also nosocomial acquired among children. The level of (IL-6) either in serum or in urine may reflect the disease severity in patients with different forms of urinary tract infection, as well as the bacterial cause implicated. So the aim of the study was to evaluate the serum IL-6 level in pediatric UTI less than 10 years in Kirkuk city Iraq. ELISA technique was performed to evaluate IL-6 level in patient's serum. The results showed that there is a relation between UTI infection and IL-6 level. Level of IL-6 elevates among children in cases of positive urine culture more than negative cases, recording (mean ± standard deviation) for positive urine culture of bacterial cause (77.56±33.84) comparing with control group (7.6±2.16). Level of IL-6 elevated among age group (6-10years) and in cases of infection with E. coli. Level of IL-6 elevate among male more than female in cases of UTI. Furthermore, children suffered cystitis recorded a higher mean value (88.21 ng/L) than children with pyelonephritis (17.83 ng/L) as well as F. value= (3.54) at df= (2) were significant at level (p ≤ 0.05).

Keywords: Interleukin 6, Pediatric UTI, cystitis, pyelonephritis, Bacterial cause

Hameed, N. W. S., Salih, S. M. & Pambuk, C. I. A. (2022). Evaluation of interleukin-6 level in the sera of children with UTI in Kirkuk city, Iraq. Journal of Current Researches on Health Sector, 12 (1), 63-74.